Causes of Acne Acne. Many consider it the bane of the Teenage years, but Acne can happen at any time in your life. Whether you are preparing for High School, or your golden years, a number of factors can contribute to Acne breakouts. What is the Cause of Acne? However, don’t give up hope. You don’t have to live with the constant threat of Zits and Pimples in your life. Causes There are numerous .